Most evidence suggests that alpha-lipoic acid, at doses of at least 300mg/day orally for 4-8 weeks improves insulin sensitivity, fasting blood glucose levels, and glucose clearance in patients with type 2 diabetes. Results showed that fasting blood glucose and HbA1c trended to decrease in a dose-dependent manner.
Findings of a review of 12 clinical trials showed that alpha-lipoic acid supplementation reduced body weight by -0.69 kg and BMI by -0.38 kg/m2 compared to the placebo group.
In another comprehensive systematic literature review of 10 articles on randomized double blind placebo controlled studies with alpha-lipoic acid, treatment showed small, yet significant short-term weight loss compared with placebo. Alpha-lipoic acid treatment demonstrated 1.27 kg greater mean weight loss compared with the placebo group.